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  • 分子生物学 | miRNA的根源区seed region - 知乎
    种子区域是指靶位点 RNA 的一个小片段，通常是 2-8 个核苷酸，它与 miRNA 的种子序列互补。 这个互补关系是 miRNA 结合到靶位点的关键，它可以导致靶位点 RNA 的降解或转录抑制 seed region 这个概念很好理解，简单来说就是miRNA与 mRNA 结合的部分，称为seed region。
  • About miRNAs, miRNA seeds, target genes and target pathways
    miRNAs are typically repressing gene expression by binding to the 3’ UTR, leading to degradation of the mRNA This process is dominated by the eight-base seed region of the miRNA Further, miRNAs are known not only to target genes but also to target
  • 种子序列_百度百科
    鉴定miRNA靶基因的最常用方法是依赖计算机算法，如TargetScan、MiRanda和PicTar，这些算法主要通过预测miRNA种子区与靶基因序列的互补结合来实现。
  • miRNA (microRNA) – Introduction | abm Inc.
    This region is called the seed region, and complementarity to this region is critical for regulation of a given gene Perfect or near perfect binding of the seed sequence to the mRNA leads to complete mRNA degradation, while imperfect binding leads to the inhibition of protein synthesis
  • 分子生物学 | miRNA的根源区seed region-腾讯云开发者社区-腾讯云
    miRNA的seed region是其与mRNA结合的关键区域，通常为2-8个核苷酸。 现有中文翻译“种子区”不够贴切，建议译为“根源区”，更能体现其在靶基因识别中的核心作用及进化保守性，有助于准确理解和科普。
  • MiRNA Targeting – Growing Beyond the Seed - PMC
    Canonically, miRNA targeting is reliant on base pairing of the seed region, nucleotides (nts) 2–7, of the miRNA to sites in mRNA 3’UTRs Recently, the 3’ half of the miRNA has gained attention for newly appreciated roles in regulating target specificity and regulation
  • What is the seed sequence of a miRNA? - QIAGEN
    The seed sequence is essential for the binding of the miRNA to the mRNA The seed sequence or seed region is a conserved heptametrical sequence which is mostly situated at positions 2-7 from the miRNA 5´-end
  • Mapping effective microRNA pairing beyond the seed using abasic . . .
    The primary element for site recognition is the seed region (nucleotides 2–8 in the miRNA), but for a minority of sites pairing outside the seed increases efficiency, with the supplementary region (nucleotides 13–16) typically having the greatest impact
  • 分子生物学 | miRNA的根源区seed region - mdnice 墨滴
    🤓 我们带着 根源区 这个翻译再去理解一下 seed region 这个概念，就会发现确实比翻译成“种子区”更加优美： miRNA与mRNA结合的区域之所以被称为根源区是因为它是靶基因识别的关键。 根源区域位于miRNA的5'端2-7个核苷酸，它与mRNA 3'UTR中的靶序列相匹配。





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