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  • Pathology Outlines - ASCUS (cytology)
    Atypical squamous cells of undetermined significance (ASCUS) refers to cellular changes that are suggestive, but not diagnostic of, low grade squamous intraepithelial lesion (LSIL)
  • Pathology Outlines - Bethesda system
    ASCUS nuclei are enlarged by 2 to 3 times, have smooth to slightly irregular nuclear membranes, finely granular chromatin, inconspicuous nucleoli and questionable cytoplasmic cavitations
  • Pathology Outlines - ASC-H (cytology)
    Atypical squamous cells - cannot exclude high grade squamous intraepithelial lesion (ASC-H) refers to cytologic changes that are suggestive of high grade squamous intraepithelial lesion (HSIL) but insufficient for a definitive interpretation
  • Pathology Outlines - Squamous dysplasia
    Can be categorized as LSIL, HSIL or atypical squamous cells of uncertain significance (ASCUS) LSIL: hyperchromasia, nuclear irregularity, koilocytotic atypia and > 3 fold nuclear enlargement compared to superficial squamous cells HSIL: small, immature appearing cells with markedly increased N:C ratio, coarse chromatin and irregular nuclear contour
  • gyncytopathcomp - PathologyOutlines. com
    This includes but not limited to: Maintenance of ASCUS to SIL ratio Histopathologic correlation of HSIL and malignant cases Five-year retrospective review of normal gynecologic specimens in patients with a new diagnosis of HSIL Using appropriate controls for each test performed; molecular, IHC, in-situ hybridization, etc
  • Pathology Outlines - Cervix
    Comprehensive resource on cervical pathology including chronic cervicitis, HPV-associated squamous cell carcinoma, adenoid basal carcinoma, and related diagnostic insights
  • Pathology Outlines - HSIL CIN II CIN III
    Precancerous squamous proliferative lesion with full thickness nuclear atypia and varying degrees of cytoplasmic maturation; driven by high risk HPV subtypes
  • Pathology Outlines - LSIL (cytology)
    Which of the following is the correct interpretation of the cervical cytology shown above from a 32 year old woman? Atypical glandular cells, NOS Atypical squamous cells of undetermined significance (ASCUS) Benign reactive squamous cells High grade squamous intraepithelial lesion (HSIL) Low grade squamous intraepithelial lesion (LSIL)
  • Pathology Outlines - HPV overview
    Cotesting with cervical cytology Reflex testing for ASCUS and in postmenopausal women, for low grade SIL Genotyping for HPV 16, 18 or 45 Follow up for abnormal cervical cytology and HPV screening with negative colposcopy Follow up after treatment for cervical precancer Cervical cancer screening guideline (J Low Genit Tract Dis 2020;24:102):
  • Pathology Outlines - Atrophy
    May cause increased incidence of ASCUS in Pap smears of peri- and post-menopausal women (Cancer 2001;93:100) Associated with scanty smears (Cytopathology 1997;8:274), ASCUS in postmenopausal women (Diagn Cytopathol 2001;24:132) Changes may disappear after topical estrogen





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