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microglia    
小神经胶质; 格子细胞

小神经胶质; 格子细胞


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  • Lipid-Laden, Sluggish Microglia? Blame Aβ. | ALZFORUM
    Microglia and macrophages make lipid droplets when stressed by inflammation Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van Dierendonck et al , 2022; reviewed by Olzmann and Carvalho, 2019) Wyss-Coray previously described lipid-droplet accumulating microglia (LDAMs) that spewed pro-inflammatory cytokines in the hippocampi of old
  • Protective Microglia Unmasked: They Act Like Regulatory T Cells
    PU 1-low microglia were rare, making up less than 1 percent of the total To a “T ” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on T cells, such as CD28, PD1, CD5, and CTLA-2 Downstream, these receptors activate phospholipase Cγ [Courtesy of Ayata et al , 2025, Nature ]
  • New PET Tracers Visualize Activated and Homeostatic Microglia
    In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people Current microglial PET tracers target the mitochondrial transporter TSPO, but TSPO crops up in other cell types as well Several groups are working on new options In one such
  • ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
    Mouse microglia got a genetic tune-up On 9 June in Nature Aging, researchers led by Warren G Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human angiotensin-converting enzyme (ACE) in mouse microglia boosts their uptake of Aβ, clearing out plaques in a model
  • A Unique Microglia Type Associated with Restricting . . . - ALZFORUM
    There are points of real interest here, and it's potentially informative to take a step back and consider what's been detected using the elegant scRNA-Seq and computational modeling approach At a first approximation, the investigators appear to have rediscovered and expression-profiled the plaque-associated macrophages (in their view, derived from microglia), which have been known in AD since
  • Expunging Microglial Lipid Droplets Boosts Phagocytosis
    Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing fluorescently labeled inactivated E Coli or Aβ What if microglia were free of excessive lipids? To find out, researchers targeted FIT2, a protein embedded in the endoplasmic reticulum that helps lipid droplets form and bud
  • Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain
    Researchers genetically engineered human iPSC-microglia to deliver neprilysin when the cells are near amyloid plaques Both local injection and brain-wide engraftment of neprilysin-secreting microglia reduced Aβ pathology Only widespread engraftment helped reduce pathologies and improve neuronal density in the subiculum





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